This is actually a know and documented issue with the F35 upgrade:
They say the likely cause is a new thing called "pipewire" not running. I just rebooted my system and try the first thing they suggest and get:su systemctl --user status wireplumber.service Failed to connect to bus: Operation not permitted (consider using --machine=This is my mistake, I should run this as a regular user, and when I do I get:@.host --user to connect to bus of other user) 
systemctl --user status wireplumber.service
● wireplumber.service - Multimedia Service Session Manager
     Loaded: loaded (/usr/lib/systemd/user/wireplumber.service; enabled; vendor...
     Active: active (running) since Fri 2022-03-18 23:53:20 MST; 13min ago
   Main PID: 2402 (wireplumber)
     CGroup: /user.slice/user-1004.slice/user@1004.service/session.slice/wirepl...
             └─2402 /usr/bin/wireplumber
So, this looks OK.  I do the next thing on the list:
systemctl --user status session.slice
● session.slice - User Core Session Slice
     Loaded: loaded (/usr/lib/systemd/user/session.slice; static)
     Active: active since Fri 2022-03-18 23:53:20 MST; 15min ago
       Docs: man:systemd.special(7)
     CGroup: /user.slice/user-1004.slice/user@1004.service/session.slice
             ├─pipewire.service
             │ └─2401 /usr/bin/pipewire
             ├─pulseaudio.service
             │ └─2555 /usr/bin/pulseaudio --daemonize=no --log-target=journal
             ├─wireplumber.service
             │ └─2402 /usr/bin/wireplumber
             ├─xdg-desktop-portal.service
             │ └─2328 /usr/libexec/xdg-desktop-portal
             └─xdg-document-portal.service
               ├─2338 /usr/libexec/xdg-document-portal
               └─2348 fusermount -o rw,nosuid,nodev,fsname=portal,auto_unmount,...
They say this is a problem (running pulseaudio alongside of pipewire and wireplumber).
The recommendation is:
su dnf swap --allowerasing pulseaudio pipewire-pulseaudioThis installs pipewire-pulseaudio and removes pulseaudio. No sound yet, but maybe we need to log in/out, restart my browser, etc. etc. I decide to cut to the chase and reboot. No sound.
They say as a "last resort" to switch back to pulseaudio, but to remove wireplumber and pipewire.
su dnf erase wireplumber dnf erase pipewire-pulseaudio dnf install pulseaudioThis takes lots of stuff with it. It takes pipewire (which is good), but also gnome-shell, gdm, xmodmap, and 27 other dependent packages. Adios. No sound yet, let's try another reboot.
systemctl --user status session.slice
● session.slice - User Core Session Slice
     Loaded: loaded (/usr/lib/systemd/user/session.slice; static)
     Active: active since Sat 2022-03-19 00:28:26 MST; 2min 29s ago
       Docs: man:systemd.special(7)
     CGroup: /user.slice/user-1004.slice/user@1004.service/session.slice
             ├─pulseaudio.service
             │ └─2474 /usr/bin/pulseaudio --daemonize=no --log-target=journal
             ├─xdg-desktop-portal.service
             │ └─2280 /usr/libexec/xdg-desktop-portal
             └─xdg-document-portal.service
               ├─2290 /usr/libexec/xdg-document-portal
               └─2300 fusermount -o rw,nosuid,nodev,fsname=portal,auto_unmount,subtype=portal -- /run/user/1004/doc
So, pulseaudio is running, but is lost at sea.
Another linux sound train wreck.
su dnf erase pulseaudio dnf install wireplumber dnf install pipewire exit systemctl --user enable --now wireplumberNote that the final command created a couple of symlinks. And voila!! Sound works now. Bravo!
Adventures in Computing / tom@mmto.org